Berberine, a traditional Chinese medicine used for over 400 years to treat gastrointestinal issues like diarrhea, has recently gained attention for its potential in weight loss. Some even call it “nature’s Ozempic.” But does it live up to the hype?
Functional medicine specialist Dr. Layth Tumah discusses the evidence surrounding berberine and weight loss. Early studies suggest that berberine may aid in fat reduction. In one clinical trial involving nonalcoholic fatty liver disease, participants who took berberine daily for three months showed significant weight loss.
Unlike many herbal weight loss products, berberine’s effectiveness is backed by scientific research. Its impact on weight loss is linked to its effect on insulin and glucose regulation. While insulin is widely known for managing blood sugar, it also plays a role in fat and protein metabolism. According to Dr. Tumah, insulin resistance, where cells fail to remove sugar from the blood efficiently, leads to elevated insulin levels, which may contribute to weight gain and metabolic issues.
However, Dr. Tumah warns that more research is needed to fully understand berberine’s role in weight loss.
Berberine works at the cellular level, interacting with multiple targets and impacting various diseases simultaneously. It enhances insulin sensitivity, improving glucose uptake into cells and reducing fat accumulation by regulating insulin’s anabolic effects. Additionally, berberine activates AMP-activated protein kinase (AMPK), an enzyme that regulates metabolism, influences fat composition, and helps manage appetite.
If you’re considering berberine supplements for weight loss, speak with a physician. It’s essential to use a high-quality, third-party verified product. Since supplements are not regulated by the U.S. Food and Drug Administration (FDA), consulting a healthcare provider is crucial, especially as berberine may interact with certain medications.
Dr. Tumah advises starting with a low dosage and gradually increasing to 500 milligrams up to three times a day, taking the supplement before or between meals.
While early studies suggest promising results, Dr. Tumah advises caution. A 2022 review of 18 studies on berberine’s impact on body weight and BMI found significant reductions, while a more recent umbrella review of meta-analyses showed improvements in blood glucose, insulin resistance, and body composition. Yet, more research is needed to confirm these findings.
Common side effects of berberine include nausea, abdominal discomfort, constipation, and diarrhea. If side effects occur, reducing the dosage can help. Berberine is not recommended for pregnant or breastfeeding women, nor for children.
Ultimately, Dr. Tumah emphasizes that berberine should complement, not replace, medical treatments. Weight management is multifactorial, and relying solely on berberine will likely not be sufficient. It should be paired with a balanced diet, regular exercise, and, if necessary, medication for optimal results.
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